讲座题目：Optical and Acoustic Siffness Measurements of mm-Sized Biomaterials: Principles, Devices and Applications for Radiation Therapy

主 讲 人：Pai-Chi Li 李百祺

主办单位：信息科学与工程学院

时  间：2024年6月11日  8:30-9:30

地  点：主楼5号会议室

主要内容：

Recent studies on drug screening and disease progression have shown that 3D cell culture systems can better represent the in vivo conditions in comparison with 2D monolayer cultures. Studying mechanobiology in 3D cell culture systems also recapitulates cell behaviors in response to various types of mechanical stimuli. An effective tool for measuring the spatiotemporal changes in elastic properties of such 3D cell culture systems without invasively contacting the samples has not been readily available but is undoubtedly needed. We have developed novel optical and acoustic shear wave imaging methods and devices for non-invasive quantification of the matrix stiffness in 3D culture conditions. Such methods require both high sensitivity and adequate spatial resolution. In particular, the complementary physical properties of light and sound are exploited and innovative devices are developed, despite the fact that these two distinctly different physical mechanisms are often separately applied in biomedical problems. Several techniques were developed, and their applications were demonstrated. In addition, we will present a simple setup for shear wave elasticity imaging using only one single element transducer with machine learning based image reconstruction. The applications of the proposed techniques in in vitro research for radiation therapy will also be presented.

个人简介：

Pai-Chi Li (李百祺) is currently a Distinguished Professor at the Department of Electrical Engineering and Institute of Biomedical Electronics and Bioinformatics at National Taiwan University. He received the B.S. degree in Electrical Engineering from National Taiwan University in 1987, and the M.S. and Ph.D. degrees from the University of Michigan, Ann Arbor in 1990 and 1994, respectively, both in Electrical Engineering: Systems.  Dr. Li is IEEE Fellow, IAMBE Fellow, AIUM Fellow and SPIE Fellow. He was also Editor-in-Chief of the Journal of Medical and Biological Engineering and has been Deputy Editor-in-Chief of Ultrasound in Medicine and Biology, Associate Editor of IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, and on the Editorial Board of Ultrasonic Imaging and Photoacoustics. He has won numerous awards including the AIUM Joseph H. Holmes Basic Science Pioneer Award, the IFMBE Otto Schmitt Award, IEEE UFFC Distinguished Lecturer Award, the IFMBE Vladimir K. Zworykin Award, etc.

主讲人照片：